Tissue Engineered Human Skin Equivalent Polyderm Model

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Project Team: V. Rai (Rutgers), Z. Zhang, Ph.D. (Rutgers)., J. Bushman, Ph.D. (Rutgers)., B. Michniak-Kohn, Ph.D. (Principal Investigator, Rutgers).

Polyderm™ is a second generation of tissue engineered skin equivalents developed in the LDD and has been created in order to produce HSEs with higher mechanical strength. For Polyderm™, an electrospun polymeric scaffold containing natural occurring extra-cellular material e.g. collagen-I is inserted into the dermis and full thickness HSE is developed using primary human derived skin cells. From initial screening studies, the model has shown improved mechanical and permeation properties over the collagen based HSEs.

Figure 1. (A & B) Schematic of electrospinning procedure; © SEM image of electrospun polymeric scaffold.

Figure 1. (A & B) Schematic of electrospinning procedure; © SEM image of electrospun polymeric scaffold.

 

Figure 2. Schematic of Polyderm™.

Figure 2. Schematic of Polyderm™.